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Sequencing and Decoding Genomes |
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Written by admin
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Sunday, 26 February 2006 |
Bioinformatics: Decoding the Genome
Lecture 1/5
Monday 27 February 2006
Extracting the fundamental genomic sequence from the DNA.
Sequencing and Decoding Genomes.
by
Jongeneel, V.
Ludwig Inst. for Cancer Research, Lausanne
Description:
Biology in the early 21st century has been radically transformed by the
availability of the full genome sequences of an ever increasing number
of life forms, from bacteria to major crop plants and to humans. The
lecture will concentrate on the computational challenges associated
with the production, storage and analysis of genome sequence data, with
an emphasis on mammalian genomes. The quality and usability of genome
sequences is increasingly conditioned by the careful integration of
strategies for data collection and computational analysis, from the
construction of maps and libraries to the assembly of raw data into
sequence contigs and chromosome-sized scaffolds. Once the sequence is
assembled, a major challenge is the mapping of biologically relevant
information onto this sequence: promoters, introns and exons of
protein-encoding genes, regulatory elements, functional RNAs,
pseudogenes, transposons, etc. The methodological approaches and data
requirements for genome annotation will be discussed, as well as user
interfaces for exploring genomes.
Copirights belong to CERN.
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