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The completion of the draft sequence of the human genome has raised public awareness of “genomics” and of the ways in which the emerging technologies of the genomics “revolution” will have direct applications to research as well as patient care.This information will be instrumental to decipher the role and function of the various elements present on our chromosomes. Microarrays, and in particular Affymetrix GeneChips®, have emerged as one very powerful technology to investigate our genome. These small glass arrays contain millions of short oligonucleotide (DNA strands) synthesized by photolithography. These tools enable to query for example the level of gene expression or the interactions of regulatory proteins with the DNA in a highly parallel manner. Cross comparisons and integration of the data using appropriate bioinformatics approaches lead to the elucidation of biological regulatory networks.